My involvement came from Liam Bruce’s honours project. Liam developed the RDB2RDF mappings that convert the existing relational content into an RDF representation. The mappings are executed using the Morph-RDB R2RML engine.
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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion
to encompass the new guide to IMMUNOPHARMACOLOGY
Harding, Simon D. and Sharman, Joanna L. and Faccenda, Elena and Southan, Christopher and Pawson, Adam J. and Ireland, Sam and Gray, Alasdair J. G. and Bruce, Liam and Alexander, Stephen P. H. and Anderton, Stephen and Bryant, Clare and Davenport, Anthony P. and Doerig, Christian and Fabbro, Doriano and Levi-Schaffer, Francesca and Spedding, Michael and Davies, Jamie A. and Nc-Iuphar
Nucleic Acids Research, 46(Database-Issue):D1091–D1106, 2018
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes ∼9000 ligands, ∼15 000 binding constants, ∼6000 papers and ∼1700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been ‘forked’ from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.
@article{Harding:GtoPdb:NAR2018,
author = {Harding, Simon D. and Sharman, Joanna L. and Faccenda, Elena and Southan, Christopher and Pawson, Adam J. and Ireland, Sam and Gray, Alasdair J. G. and Bruce, Liam and Alexander, Stephen P. H. and Anderton, Stephen and Bryant, Clare and Davenport, Anthony P. and Doerig, Christian and Fabbro, Doriano and Levi{-}Schaffer, Francesca and Spedding, Michael and Davies, Jamie A. and Nc{-}Iuphar},
title = {The {IUPHAR/BPS} Guide to {PHARMACOLOGY} in 2018: updates and expansion
to encompass the new guide to {IMMUNOPHARMACOLOGY}},
journal = {Nucleic Acids Research},
volume = {46},
number = {Database-Issue},
pages = {D1091--D1106},
year = {2018},
url = {https://doi.org/10.1093/nar/gkx1121},
doi = {10.1093/nar/gkx1121}
}
About Me
I'm an Associate Professor in Computer Science at Heriot-Watt University. My research focuses on linking datasets.
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